A new injectable HIV prevention drug, lenacapivir, is being hailed as a major breakthrough in the fight against HIV, with health officials saying it could significantly reduce new infections in South Africa.
Unlike daily pre-exposure prophylaxis (PrEP), the injection is administered once every six months, offering continuous protection over that period. Health experts believe this could improve adherence, particularly among individuals who struggle to take daily medication consistently.
The Department of Health has described the treatment as an important addition to existing prevention methods, which include condoms, PrEP and post-exposure prophylaxis (PEP).
Medical professionals say the injectable option addresses one of the biggest challenges in HIV prevention — missed doses. By reducing the need for daily medication, it may help more people maintain consistent protection.
However, experts caution that the drug is not a standalone solution. Safe sexual practices and regular prevention measures remain essential, particularly to protect against other infections.
The rollout of lenacapivir will be phased, beginning at selected sites across the country, mainly in high-risk areas. Priority will be given to groups most vulnerable to HIV infection, including sex workers, men who have sex with men, adolescent girls and young women, and pregnant or breastfeeding women.
Access may initially be limited due to supply constraints, with current stock expected to cover only a portion of demand. In the private sector, availability may depend on affordability, while public access will be restricted to designated facilities.
Advocates say the success of the programme will depend not only on access, but also on education and awareness. Addressing stigma, improving understanding of the treatment and ensuring patients return for follow-up injections will be key to its impact.
While challenges remain, healthcare providers are optimistic that the introduction of long-acting prevention tools like lenacapivir could play a significant role in reducing new HIV infections and supporting the country’s goal of ending HIV as a public health threat by 2030.
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